Metabolic regulation of apoptosis via Ca+/Calmodulin Kinase II (CaMKII)
نویسندگان
چکیده
Background The metabolic state of a cell is an important factor in whether or not it engages its apoptotic machinery. Furthermore, reprogramming energy metabolism is now recognized as a hallmark of cancer; so understanding how metabolism regulates apoptosis is crucial. Recently it has been demonstrated that CaMKII serves as a link between metabolic state and apoptosis [1]. Using the Xenopus laevis oocyte extract, it was shown that addition of glucose-6-phosphate (G6P) induced an inhibitory phosphorylation of caspase 2, mediated via CaMKII. However, the mechanisms of how G6P and metabolism regulate CaMKII still remain unclear. The aim of this study is to investigate the underlying mechanisms of how metabolism regulates CaMKII activity.
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2012